Potential pancreatic lipase inhibitory activity of phenolic constituents from the root bark of Morus alba L

Bioorg Med Chem Lett. 2016 Jun 15;26(12):2788-2794. doi: 10.1016/j.bmcl.2016.04.066. Epub 2016 Apr 23.

Abstract

Detailed phytochemical investigation from the root bark of Morus alba resulted in the isolation of eleven new compounds, including seven 2-arylbenzofuran derivatives (morusalfurans A-G), three flavonoids (morusalnols A-C), and one geranylated stilbene (morusibene A), as well as 22 known compounds. The structures of the identified compounds were elucidated based on a comprehensive analysis of spectroscopic data and Mosher's method. Compounds 2, 3, 6-8, 11, 23, 24, and 29 showed potent inhibition of PL in comparison with the positive control treatment (orlistat, IC50=0.012μM), with IC50 values ranging from 0.09 to 0.92μM.

Keywords: 2-Arylbenzofuran; Geranylated stilbene; Moraceae; Morus alba; Pancreatic lipase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Lipase / antagonists & inhibitors*
  • Lipase / metabolism
  • Molecular Structure
  • Pancreas / drug effects*
  • Pancreas / enzymology
  • Plant Bark / chemistry*
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Plant Roots / chemistry*
  • Structure-Activity Relationship

Substances

  • Enzyme Inhibitors
  • Plant Extracts
  • Lipase